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Introduction: Vrana (wound) management is a vital component of Ayurvedic therapeutics, addressed extensively in the Samhitas. Sushruta Samhita, in particular, provides comprehensive insight into types of wounds, their etiopathogenesis, classification, and management protocols. Ayurveda emphasizes both local wound care and systemic correction, integrating medicinal, surgical, and lifestyle approaches.  Methods: A narrative review was conducted using classical Ayurvedic texts (Sushruta Samhita, Charaka Samhita, Ashtanga Hridaya) and contemporary literature indexed in PubMed, Scopus, and Web of Science. Search terms included “Vrana Chikitsa,” “Ayurvedic wound healing,” and “Sushruta Samhita wound management.” Inclusion criteria were classical descriptions, experimental studies, and clinical trials evaluating Ayurvedic interventions. Exclusion criteria were anecdotal reports and non-peer-reviewed sources. Results: The Samhitas describe various types of wounds—acute (Kshata Vrana), chronic (Dushta Vrana), traumatic, and surgical—along with their specific etiologies, Dosha involvement, and clinical features. Therapeutic approaches include Shodhana (purification), Shamana (palliative therapy), Kalka (medicated pastes), Taila (oils), Rasayana, and surgical techniques like excision, suturing, and cauterization. Modern research validates several Ayurvedic formulations for antimicrobial, anti-inflammatory, and wound-healing properties. Discussion: Ayurvedic wound management provides a holistic approach that complements modern strategies. Integrating classical therapies with contemporary wound care may improve outcomes, particularly in chronic, non-healing wounds. Conclusion: Vrana Chikitsa as described in Samhitas presents a scientifically robust framework for wound management. Translational research and clinical validation can facilitate integration into modern healthcare, enhancing patient care and reducing complications.

KEYWORDS: Ayurveda, Dushta Vrana, Shodhana, Vrana Chikitsa, Wound Healing