Become A Member

Introduction: Ghrita (medicated ghee) and Taila (medicated oils) are cornerstone therapeutic agents in Ayurveda, widely used for internal and external administration. Classical texts describe their preparation, pharmacological properties, and clinical applications, emphasizing their role in disease management, rejuvenation, and enhancing bioavailability of herbal drugs. Methods: A systematic review of classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya) and modern databases (PubMed, Scopus, Web of Science, Google Scholar) was conducted. Keywords included “Ghrita,” “Taila,” “medicated ghee,” “medicated oils,” and “Ayurvedic lipid formulations.” Studies describing preparation, pharmacology, and clinical efficacy were included; anecdotal or non-peer-reviewed sources were excluded. Results: Samhitas detail various Ghrita and Taila formulations, such as Brahmi Ghrita, Mahatikta Ghrita, Dhanwanthari Taila, and Mahanarayana Taila, used for neurological, dermatological, musculoskeletal, and geriatric conditions. Pharmacologically, these lipid-based formulations enhance absorption of active constituents, provide neuroprotection, anti-inflammatory effects, and promote rejuvenation. Modern studies validate antioxidant, cognitive-enhancing, analgesic, and wound-healing properties of selected Ghrita and Taila preparations. Discussion: Ghrita and Taila exemplify lipid-based drug delivery in Ayurveda. Despite proven efficacy, challenges include standardization, quality control, and lack of large-scale clinical trials. Modern research using pharmacokinetic and pharmacodynamic studies can provide evidence-based validation and integration into contemporary therapeutics. Conclusion: Ghrita and Taila formulations are scientifically rational, clinically relevant, and historically validated therapeutic agents. Evidence-based standardization and integration into modern healthcare can optimize therapeutic outcomes, especially in neurodegenerative, metabolic, and musculoskeletal disorders.

KEYWORDS: Ayurveda, Ghrita, Lipid formulations, Taila, Therapeutics