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Introduction: Marma points are vital anatomical locations described in Ayurvedic Samhitas, representing intersections of muscles, vessels, ligaments, joints, and bones. They are considered critical for maintaining health, preventing disease, and managing trauma. Proper understanding of Marma has implications in surgical procedures, physiotherapy, pain management, and rejuvenation therapies. Methods: A comprehensive review of classical Ayurvedic texts (Sushruta Samhita, Charaka Samhita, Ashtanga Hridaya) and modern literature from PubMed, Scopus, Web of Science, and Google Scholar was conducted. Search terms included “Marma points,” “Ayurvedic trauma management,” “Samhita surgical points,” and “Marma therapy.” Studies reporting anatomical, therapeutic, or clinical applications were included; anecdotal and non-peer-reviewed sources were excluded. Results: Samhitas classify Marma based on location, severity of injury, and involvement of Doshas and Dhatus. Classical texts describe 107 Marma points with details regarding structure, function, trauma management, and therapeutic stimulation. Clinical applications include pain relief, neurological disorders, musculoskeletal rehabilitation, and surgical safety. Modern research validates specific Marma points for neurovascular interventions, acupressure, and physiotherapeutic applications. Discussion: Marma knowledge integrates anatomical, physiological, and therapeutic principles. Clinical application in modern practice enhances pain management, rehabilitation, and preventive care. However, standardization, precise localization, and evidence-based studies are limited, necessitating further research. Conclusion: Marma-based interventions provide a holistic framework for clinical applications. Integrating classical knowledge with modern anatomical and therapeutic research can optimize patient outcomes, minimize surgical risks, and enhance rehabilitative care.

KEYWORDS: Acupressure, Ayurveda, Marma, Rehabilitation, Traum