Become A Member

Introduction: Polyherbal formulations are a central component of Ayurvedic therapeutics, described extensively in classical Samhitas. They combine multiple herbs to achieve synergistic therapeutic effects, enhance bioavailability, reduce toxicity, and target multiple pathophysiological mechanisms simultaneously. These formulations have been traditionally used for metabolic, neurological, inflammatory, and chronic diseases. Methods: A systematic review was conducted using classical texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya) and modern scientific databases (PubMed, Scopus, Web of Science, Google Scholar). Keywords included “polyherbal formulations,” “Ayurvedic polyherbs,” “Samhita therapeutics,” and “Ayurvedic combinations.” Inclusion criteria comprised classical descriptions, preclinical and clinical studies on polyherbal formulations. Exclusion criteria included anecdotal reports or non-peer-reviewed sources. Results: Samhitas describe numerous polyherbal formulations, such as Triphala, Chyawanprash, Hingvashtaka, and Dashamoola, employed in digestive, neurological, respiratory, and musculoskeletal disorders. Modern research validates pharmacological activities including antioxidant, anti-inflammatory, hepatoprotective, immunomodulatory, and neuroprotective effects. Synergistic interactions among herbs improve therapeutic efficacy and reduce adverse effects. Discussion: Polyherbal formulations reflect a holistic approach to treatment in Ayurveda. Despite classical validation, challenges remain in standardization, quality control, and clinical validation. Integration of modern analytical, pharmacokinetic, and clinical methodologies can provide evidence-based support for these formulations, bridging traditional knowledge and contemporary medicine. Conclusion: Polyherbal formulations from Samhitas offer scientifically rational, clinically relevant therapeutic options. Evidence-based research, standardization, and translational studies are essential to optimize their clinical application in modern healthcare.

KEYWORDS: Ayurveda, Herbal synergy, Polyherbal formulations, Samhita, Therapeutics