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Introduction: Ojas is considered the vital essence of all bodily tissues in Ayurveda, responsible for immunity, vitality, and overall well-being. Classical Samhitas describe Ojas as the end-product of Dhatu metabolism, linking physical, mental, and spiritual health. Its depletion or vitiation is associated with increased susceptibility to disease and diminished strength. Methods: A comprehensive literature review was conducted using classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya) and modern databases (PubMed, Scopus, Web of Science). Keywords included “Ojas,” “Ayurveda,” “Samhita,” “immunity,” and “vitality.” Inclusion criteria encompassed classical references and peer-reviewed studies exploring Ojas physiology, pathology, and clinical relevance. Exclusion criteria included anecdotal reports and non-peer-reviewed sources. Results: Classical texts describe Ojas as the subtle essence formed from the proper nourishment of Dhatus and regulated by Agni (metabolic fire). Modern interpretations correlate Ojas with immune competence, hormonal balance, neuroendocrine function, and stress resilience. Clinical studies support its role in physical stamina, mental health, and disease resistance. Discussion: Integrating classical and modern perspectives on Ojas provides a framework for preventive and regenerative healthcare. While classical texts emphasize dietary, lifestyle, and Rasayana interventions to maintain Ojas, modern research highlights immunomodulatory, adaptogenic, and psychosomatic correlates. Challenges include standardizing assessment and measuring its physiological correlates. Conclusion: Ojas remains a central concept linking Ayurveda to holistic health and immunity. Translational research integrating classical principles with modern science can enhance personalized, preventive, and therapeutic healthcare.

KEYWORDS: Ayurveda, Immunity, Ojas, Samhita, Vitality