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Introduction: Anjana Kalpana, the application of collyrium formulations, is an important ocular therapeutic modality described in classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya). These formulations are used for prevention and management of various eye disorders, including conjunctivitis, cataract, and chronic ocular infections. The therapeutic rationale emphasizes purification, strengthening of ocular tissues, and restoration of visual function. Methods: A systematic literature review was conducted using classical texts and modern databases (PubMed, Scopus, Web of Science, Google Scholar). Keywords included “Anjana,” “Ayurvedic ocular therapy,” “Samhita eye formulations,” and “ocular diseases Ayurveda.” Inclusion criteria included classical descriptions, preclinical and clinical studies on Anjana formulations. Exclusion criteria included anecdotal or non-peer-reviewed reports. Results: Samhitas describe various Anjana formulations based on herbs (Triphala, Haridra, Yashtimadhu) and mineral preparations (Parada, Gandhaka), prepared as powdered, paste, or paste-suspension forms. Therapeutic indications include corneal and conjunctival disorders, night blindness, and visual fatigue. Modern pharmacological studies demonstrate antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory properties. Clinical studies report improvement in visual acuity, reduced ocular irritation, and prevention of infection. Discussion: Anjana formulations illustrate the integration of preventive and curative ophthalmic care in Ayurveda. Despite promising classical and modern evidence, challenges remain in standardization, formulation stability, and large-scale clinical validation. Evidence-based studies and analytical standardization can bridge classical knowledge with modern ophthalmology. Conclusion: Anjana Kalpana provides scientifically rational and clinically relevant ocular therapeutics. Standardization, safety evaluation, and translational research are essential for their integration into modern clinical practice.

KEYWORDS: Anjana, Ayurvedic ophthalmology, Eye disorders, Samhita, Therapeutics